- Keyto Health offers a Mediterranean-style low carb program that is delivered through a mobile app and includes the Keyto Breath Sensor.
- A randomized clinical trial found that participants following the Keyto program lost over 2x more weight than participants following the Weight Watchers (WW) program after 12 weeks, and 3x as much after 24 weeks.
- Compared to the WW group, the Keyto group had significant improvements in markers of metabolic health, and there were no concerning changes in cholesterol or other lipids.
- Participants rated the Keyto program significantly easier to follow than the WW program.
San Francisco, CA, June 14, 2021 – Keyto Health, a technology-enabled health and weight loss company, announced findings today of a 155 person randomized clinical trial (RCT) comparing the Keyto Mediterranean-style low carb program to the Weight Watchers’ (WW) calorie-restricted low-fat program in promoting weight loss. The peer-reviewed study was conducted by investigators from the University of British Columbia during the COVID-19 pandemic, and published in the Journal of the Obesity Society.
The trial found that participants in the Keyto group lost twice as much weight as participants in the WW group after 12 weeks (12.5 lbs vs 5.5 lbs), and nearly three times as much (18.3 lbs vs 6.2 lbs) after 24 weeks. The 24 week weight loss represented 8.7% body weight in the Keyto group vs 3.1% in the WW group.
The study also assessed metabolic and cardiovascular risk markers with blood samples at baseline and after 12 weeks. Hemoglobin A1C (HbA1c), a diabetes marker, and ALT, a liver function test, were both improved to a greater extent in the Keyto group compared to the WW group. Despite previous concerns about the effect of ketogenic diets on LDL cholesterol, researchers found there were no significant differences between the Keyto Mediterranean-style program and the WW program in LDL cholesterol or other lipids.
“We are very pleased with the results, which showed that with our Mediterranean-style program, you can achieve all the weight loss and metabolic benefits of a ketogenic diet without any adverse effect on LDL cholesterol,” said Ethan J. Weiss, M.D., a Medical Advisor to Keyto, and Associate Professor of Cardiology at UCSF. “The magnitude of weight loss in the Keyto group was quite spectacular and unprecedented for a fully virtual randomized study, especially given that it was conducted through the peak of the global COVID-19 pandemic.”
About the KEYTO vs WW Trial
The trial was conducted among 155 participants with overweight or obesity and randomized to either Keyto or WW. Both interventions were delivered entirely via mobile app. All participants received a wireless scale for recording weights. A third-party laboratory collected blood samples at baseline and 12 weeks.
At 12 weeks, weight loss was greater for the Keyto group (-5.6 kg; 95% CI, -6.7 kg to -4.5 kg) compared to the WW group (-2.5 kg; 95% CI, -3.6 kg to -1.4 kg).The between-group difference was a 3.1 kg greater weight loss for the Keyto group (95% CI, -4.6 kg to -1.5 kg; p < 0.001). 24 week data showed the durability of the superiority of Keyto over WW, with Keyto users losing 5.5 kg more than WW users (95% CI, -8.3 kg to -2.8 kg; p < 0.001).
Secondary/exploratory outcomes of HbA1c (a marker of blood sugar levels over the past three months) and ALT (a liver enzyme that’s a marker of damage in liver cells) were improved to a greater extent in the Keyto group compared to the WW group (p < 0.01). Users in the Keyto group reported better sleep quality compared to the WW group, as measured by the Pittsburgh Sleep Quality Index (p = .04).
Participant surveys, conducted weekly, found that the Keyto program was significantly easier to follow than the WW program (p < .001). Food recall surveys found that there were no significant differences in self-reported energy intake between groups across the 12 weeks. The Keyto group reported consuming significantly less carbohydrates than the WW group.
“We know from past studies that ketogenic diets lead to weight loss. What is most intriguing from this trial is that the Keyto program – which uses an app with breath acetone biofeedback – was so effective for weight loss when tested in the real-world with essentially no interaction with study staff,” said Jonathan Little, PhD, faculty member of UBC, and the Principal Investigator of the study. “In addition, the trial was designed to compare Keyto to a proven low-fat weight loss app and we found that those following the Keyto program lost, on average, twice as much weight.”
The full paper, Keyto App and Device versus WW App on Weight Loss and Metabolic Risk in Adults with Overweight or Obesity: A Randomized Trial, is available online here.
About KEYTO HEALTH
Keyto offers a personalized low-carb program, which includes a Mediterranean-style option. The program is delivered through a mobile app, and features the Keyto course, a data-driven lesson plan that ingrains core principles and introduces members to a searchable food database, recipes, meal plans, and members-only podcast. All Keyto members get personalized support from a goal specialist, dietician, and personal trainer.
The Keyto Health program also includes the Keyto Breath Sensor, which measures breath acetone to give insight on if one is metabolizing fat or sugar for energy. The device eliminates confusion on whether a member is eating the right foods to reach their goal, and provides motivation and confidence beyond weight scale measurements.
Keyto was founded by Ray Wu M.D., Liane Nakamura, and Ethan J. Weiss M.D.
About COVID-19 IMPACT
The RCT started enrollment in January 2020, and was conducted virtually through the global COVID-19 pandemic.
In a survey on the impact of COVID-19 on following their assigned diet, Keyto participants rated that COVID-19 made it easier to stick to the Keyto program, while WW users rated that COVID-19 made it more difficult to stick to the WW program.
There was no significant difference in the impact of COVID-19 to get food between the two groups.